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Dehalogenation using Grignard reagents is a two steps hydrodehalogenation process. The reaction begins with the formation of alkyl/arene-magnesium-halogen compound, followed by addition of proton source to form dehalogenated product.
Reductive dehalogenases (EC 1.97.1.8) are a group of enzymes utilized in organohalide respiring bacteria. [1] [2] These enzymes are mostly attached to the periplasmic side of the cytoplasmic membrane and play a central role in energy-conserving respiratory process for organohalide respiring bacteria by reducing organohalides.
[1] 2-Oxyallyl metal intermediates may also intercept nucleophiles in a process that involves umpolung at the α carbon. [2] In addition, because reduction of monohalo ketones produces enolates in a site-specific fashion, reactions associated with enolates ( alkylation , aldol , Michael ) may be carried out using halo ketone substrates under ...
When treated with a strong base many alkyl chlorides convert to corresponding alkene. [1] It is also called a β-elimination reaction and is a type of elimination reaction. ...
Halogenated organic compounds are used as the terminal electron acceptor, which results in their dehalogenation. [6] Reductive dehalogenation is the process by which this occurs. [6] It involves the reduction of halogenated compounds by removing the halogen substituents, while simultaneously adding electrons to the compound. [7]
In chemistry, halogenation is a chemical reaction which introduces one or more halogens into a chemical compound. Halide-containing compounds are pervasive, making this type of transformation important, e.g. in the production of polymers, drugs. [1]
Mechanistic diagram of the reductive dehalogenation of unactivated carbon-iodine bonds. Like tin-mediated radical dehalogenation reactions, photocatalytic reductive dehalogenation can be used to initiate cascade cyclizations [9] Diagram of a radical cascade cyclization initiated by a photoredox-catalyzed reductive dehalogenation reaction.
Dehalogenation in aerobic organisms is usually done through oxidation and hydrolysis; [9] however, iodotyrosine deiodinase uses reductive dehalogenation. Iodotyrosine deiodinase and iodothyronine deiodinase have been determined as the only two known enzymes to catalyze reductive dehalogenation in mammals. [ 8 ]