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Time-resolved RNA sequencing methods are applications of RNA-seq that allow for observations of RNA abundances over time in a biological sample or samples. Second-Generation DNA sequencing has enabled cost effective, high throughput and unbiased analysis of the transcriptome . [ 1 ]
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The transcriptome is the set of all RNA transcripts, including coding and non-coding, in an individual or a population of cells. The term can also sometimes be used to refer to all RNAs , or just mRNA , depending on the particular experiment.
The word "transcriptome" was first used in the 1990s. [19] [20] In 1995, one of the earliest sequencing-based transcriptomic methods was developed, serial analysis of gene expression (SAGE), which worked by Sanger sequencing of concatenated random transcript fragments. [21] Transcripts were quantified by matching the fragments to known genes.
TSP stands for "Time Series Processor", although it is also commonly used with cross section and panel data. The program was initially developed by Robert Hall during his graduate studies at Massachusetts Institute of Technology in the 1960s. [ 1 ]
A time series database is a software system that is optimized for storing and serving time series through associated pairs of time(s) and value(s). [1] In some fields, time series may be called profiles, curves, traces or trends. [ 2 ]
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