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Angioedema is an area of swelling of the lower layer of skin and tissue just under the skin or mucous membranes. [1] [3] The swelling may occur in the face, tongue, larynx, abdomen, or arms and legs. [1] Often it is associated with hives, which are swelling within the upper skin. [1] [3] Onset is typically over minutes to hours. [1]
In the unusual cases reported where it affects the upper lip, this may be due to upper lip prominence. [7] The commissures (corners of the mouth) are not usually involved. [2] [6] Affected individuals may experience symptoms such as a dry sensation and cracking of the lips. [7] It is usually painless and persistent. The appearance is variable.
Chapped lips (also known as cheilitis simplex [5] or common cheilitis) [6] is characterized by the cracking, fissuring, and peeling of the skin of the lips, and is one of the most common types of cheilitis. [5] [7] While both lips may be affected, the lower lip is the most common site. [7]
Shortness of breath is the most common symptom, followed by face or arm swelling. [5] Following are frequent symptoms: Difficulty breathing [6] Headache [6] Facial swelling [6] Venous distention in the neck and distended veins in the upper chest and arms [6] Migraines (especially if unusual to normal) Large decrease in lung capacity
The enlargement can cause midline fissuring of the lip ("median cheilitis") or angular cheilitis (sores at the corner of the mouth). The swelling is non-pitting (c.f. pitting edema) and feels soft or rubbery on palpation. The mucous membrane of the lip may be erythematous (red) and granular. [2] One or both lips may be affected. [3]
Hereditary angioedema (HAE) is a disorder that results in recurrent attacks of severe swelling. [3] The swelling most commonly affects the arms, legs, face, intestinal tract, and airway. [3] If the intestinal tract is affected, abdominal pain and vomiting may occur. [1] Swelling of the airway can result in its obstruction and trouble breathing. [1]
Melkersson–Rosenthal syndrome is a rare neurological disorder characterized by recurring facial paralysis, swelling of the face and lips (usually the upper lip: cheilitis granulomatosis) and the development of folds and furrows in the tongue (fissured tongue). [2]: 799 Onset is in childhood or early adolescence.
The most common causes of enlargement of the submandibular lymph nodes are infections of the head, neck, ears, eyes, nasal sinuses, pharynx, and scalp. [1] The lymph glands may be affected by metastatic spread of cancers of the oral cavity, anterior portion of the nasal cavity, soft tissues of the mid-face, and submandibular salivary gland. [1]