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12-lead electrocardiogram showing ST-segment elevation (orange) in I, aVL and V1–V5 with reciprocal changes (blue) in the inferior leads, indicative of an anterior wall myocardial infarction. When there is a blockage of the coronary artery , there will be lack of oxygen supply to all three layers of cardiac muscle (transmural ischemia).
ST elevation ≥1 mm in a lead with a positive QRS complex (i.e.: concordance) - 5 points; concordant ST depression ≥1 mm in lead V1, V2, or V3 - 3 points; ST elevation ≥5 mm in a lead with a negative (discordant) QRS complex - 2 points; ≥3 points = 90% specificity of STEMI (sensitivity of 36%) [2]
ST elevation may indicate transmural myocardial infarction. An elevation of >1mm and longer than 80 milliseconds following the J-point . This measure has a false positive rate of 15-20% (which is slightly higher in women than men) and a false negative rate of 20–30%.
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The 2018 European Society of Cardiology/American College of Cardiology Foundation/American Heart Association/World Health Federation Universal Definition of Myocardial Infarction for the ECG diagnosis of the ST segment elevation type of acute myocardial infarction require new ST elevation at J point of at least 1mm (0.1 mV) in two contiguous leads with the cut-points: ≥1 mm in all leads ...
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The TIMI risk score can identify high risk patients in ST-elevation and non-ST segment elevation MI ACS [30] [31] and has been independently validated. [ 32 ] [ 33 ] Based on a global registry of 102,341 patients, the GRACE risk score estimates in-hospital, 6 months, 1 year, and 3-year mortality risk after a heart attack. [ 34 ]