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In organic chemistry, a cross-coupling reaction is a reaction where two different fragments are joined. Cross-couplings are a subset of the more general coupling reactions. Often cross-coupling reactions require metal catalysts. One important reaction type is this:
The most common type of coupling reaction is the cross coupling reaction. [1] [2] [3] Richard F. Heck, Ei-ichi Negishi, and Akira Suzuki were awarded the 2010 Nobel Prize in Chemistry for developing palladium-catalyzed cross coupling reactions. [4] [5] Broadly speaking, two types of coupling reactions are recognized:
In cross-coupling reactions, the component reagents are called cross-coupling partners or simply coupling partners. These reagents can be further classified according to their nucleophilic vs electrophilic character: R-X + R'-Y → R-R' + XY. Typically the electrophilic coupling partner (R-X) is an aryl halide, but triflates are also used ...
The coupling of 2-chlorobenzoic acid and aniline is illustrative: [4] C 6 H 5 NH 2 + ClC 6 H 4 CO 2 H + KOH → C 6 H 5 N(H)−C 6 H 4 CO 2 H + KCl + H 2 O. A typical catalyst is formed from copper(I) iodide and phenanthroline. The reaction is an alternative to the Buchwald–Hartwig amination reaction.
In Suzuki-Miyaura cross-couplings, the traditional coupling partners are organobromides and organoboron compounds. While Suzuki-Miyaura cross-couplings typically employ organobromides as coupling partners, organochlorides are more desirable electrophiles for cross-coupling due to their lower cost. The sluggish reactivity of the C-Cl bond is ...
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Some of the cross-coupling reactions that include a transmetalation step are Stille cross-coupling, Suzuki cross-coupling, Sonogashira cross-coupling, and Negishi cross-coupling. The most useful cross-coupling catalysts tend to be ones that contain palladium. Cross-coupling reactions have the general form of R′–X + M–R → R′–R + M ...
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