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  2. Conivaptan - Wikipedia

    en.wikipedia.org/wiki/Conivaptan

    Conivaptan, sold under the brand name Vaprisol, is a non-peptide inhibitor of the receptor for anti-diuretic hormone, also called vasopressin. It was approved in 2004 for hyponatremia (low blood sodium levels). The compound was discovered by Astellas and marked in 2006. The drug is now marketed by Cumberland Pharmaceuticals, Inc.

  3. Aquaretic - Wikipedia

    en.wikipedia.org/wiki/Aquaretic

    Synthetic aquaretics are vasopressin receptor antagonists and include conivaptan, tolvaptan, demeclocycline, and mozavaptan (OPC-31260), as well as lithium. Conivaptan hydrochloride and tolvaptan have been approved by the FDA for treating syndrome of inappropriate antidiuretic hormone. [4] [5] Mozavaptan is approved in Japan. [citation needed]

  4. Vasopressin receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/Vasopressin_receptor...

    The "vaptan" drugs act by directly blocking the action of vasopressin at its receptors (V 1A, V 1B and V 2).These receptors have a variety of functions, with the V 1A and V 2 receptors are expressed peripherally and involved in the modulation of blood pressure and kidney function respectively, while the V 1A and V 1B receptors are expressed in the central nervous system.

  5. 19 drug approvals in 2024 that had 'big clinical impact ... - AOL

    www.aol.com/news/19-drug-approvals-2024-had...

    GoodRx released a list of 19 of the most influential drugs and vaccines approved by the FDA in 2024 to treat a variety of conditions. These medications are “slated to make a big clinical impact."

  6. Tolvaptan - Wikipedia

    en.wikipedia.org/wiki/Tolvaptan

    Tolvaptan was approved by the U.S. Food and Drug Administration (FDA) on May 19, 2009, and is sold by Otsuka Pharmaceutical Co. under the trade name Samsca. [9] Tolvaptan, as Jynarque, was granted approval for medical use in the United States in April 2018. [10]

  7. AOL Mail

    mail.aol.com

    Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!

  8. US FDA grants full approval for Pfizer's cervical cancer drug

    www.aol.com/news/us-fda-grants-full-approval...

    The treatment, Tivdak - an antibody-drug conjugate co-developed by Genmab A/S and Seagen - received the FDA's accelerated approval for the same indication in 2021. It was added to Pfizer's ...

  9. Osmotherapy - Wikipedia

    en.wikipedia.org/wiki/Osmotherapy

    This can be prevented by administration of conivaptan, a safe FDA approved drug that treats euvolemic hyponatremia. Through the process of aquaresis, conivapten which is a vasopressin receptor antagonist improves serum sodium concentration while eliminating free water without having any negative effect on systolic blood pressure and pulse rate ...