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Megaloblastic anaemia; Methaemoglobinaemia; Erythema multiforme; Low blood sugar; Hepatitis (liver swelling); Crystalluria (crystals in the urine); Urinary obstruction causing difficulty passing urine
Common side effects include nausea, vomiting, rash, and diarrhea. [2] Severe allergic reactions and Clostridioides difficile infection may occasionally occur. [2] Its use in pregnancy is not recommended. [2] [19] It appears to be safe for use during breastfeeding as long as the baby is healthy. [19]
Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections. [1] Other uses include for middle ear infections and travelers' diarrhea. [1] With sulfamethoxazole or dapsone it may be used for Pneumocystis pneumonia in people with HIV/AIDS.
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Sulfamethoxazole (SMZ or SMX) is an antibiotic.It is used for bacterial infections such as urinary tract infections, bronchitis, and prostatitis and is effective against both gram negative and positive bacteria such as Escherichia coli and Listeria monocytogenes.
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The use of TMP/SMX also raises concerns in patients with kidney disease. In patients with creatinine clearance less than 50 mL/min, the urine concentrations of SMX may decrease to subtherapeutic levels. Therefore, in patients with low creatinine clearance, it is recommended to prescribe a reduced dosage of TMP alone. [30]
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