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The distal convoluted tubule (DCT) is a portion of kidney nephron between the loop of Henle and the collecting tubule. Physiology. It is partly responsible for the ...
The distal convoluted tubule has a different structure and function to that of the proximal convoluted tubule. Cells lining the tubule have numerous mitochondria to produce enough energy for active transport to take place. Much of the ion transport taking place in the distal convoluted tubule is regulated by the endocrine system.
It is adjacent to the distal convoluted tubule, the most distal segment of the renal tubule. Connecting tubules from several adjacent nephrons merge to form cortical collecting tubules, and these may join to form cortical collecting ducts (CCD). [1] Connecting tubules of some juxtamedullary nephrons may arch upward, forming an arcade. It is ...
In the kidney, the macula densa is an area of closely packed specialized cells lining the wall of the distal tubule where it touches the glomerulus. Specifically, the macula densa is found in the terminal portion of the distal straight tubule (thick ascending limb of the loop of Henle), after which the distal convoluted tubule begins. [1] [2] [3]
At this location, in the wall of the last portion of distal straight tubule, there is a modified region of tubular epithelium called the macula densa.(Fig. 5 in Kumaran and Hanukoglu 2020) [5] Cells in the macula densa respond to changes in the sodium chloride levels in the distal tubule of the nephron via the tubuloglomerular feedback (TGF
The cortical thick ascending limb drains urine into the distal convoluted tubule. [3] The tissue type of the loop is simple squamous epithelium. The "thick" and "thin" terminology does not refer to the size of the lumen, but to the size of the epithelial cells. [4] The loop is also sometimes called the nephron loop. [citation needed]
This illustration demonstrates the normal kidney physiology, including the Proximal Convoluted Tubule (PCT), Loop of Henle, and Distal Convoluted Tubule (DCT). It also includes illustrations showing where some types of diuretics act, and what they do. Renal physiology (Latin renes, "kidneys") is the study of the physiology of the kidney.
The distal tubule of the mammalian kidney is the portion of the nephron located between the macula densa region and the cortical collecting tubule. It consists of various subsegments that differ in structure and function, and it is responsible for reabsorbing 5-10% of filtered sodium and chloride under normal circumstances, as well as playing a ...