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Vitamin B 3, colloquially referred to as niacin, is a vitamin family that includes three forms, or vitamers: niacin (nicotinic acid), nicotinamide (niacinamide), and nicotinamide riboside. [1] All three forms of vitamin B 3 are converted within the body to nicotinamide adenine dinucleotide (NAD). [1]
Nicotinamide riboside (NR, SR647) is a pyridine-nucleoside and a form of vitamin B 3. It functions as a precursor to nicotinamide adenine dinucleotide , or NAD+ , [ 2 ] through a two-step and a three-step pathway.
Nicotinamide (INN, BAN UK [2]) or niacinamide (USAN US) is a form of vitamin B 3 found in food and used as a dietary supplement and medication. [ 3 ] [ 4 ] [ 5 ] As a supplement, it is used orally (swallowed by mouth) to prevent and treat pellagra (niacin deficiency). [ 4 ]
You have to have NAD precursors”—that is, five predominant chemicals that combine to make up the NAD+ molecule, including NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide).
Nicotinamide mononucleotide ("NMN" and "β-NMN") is a nucleotide derived from ribose, nicotinamide, nicotinamide riboside and niacin. [1] In humans, several enzymes use NMN to generate nicotinamide adenine dinucleotide (NADH). [ 1 ]
Brenner is a major contributor in the field of nicotinamide adenine dinucleotide (NAD) metabolism and has developed targeted, quantitative methods for NAD metabolomics. [3] Brenner discovered eukaryotic nicotinamide riboside (NR) kinase and nucleosidase pathways to NAD.
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