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Permanent damage to these beta cells results in Type 1, or insulin-dependent diabetes, for which exogenous insulin replacement therapy is the only answer. Diabetes mellitus is a disease in which the beta cells of the endocrine pancreas either stop producing insulin or can no longer produce it in enough quantity for the body's needs. The disease ...
The vast majority of cats present with diabetes mellitus, the possibility of hypersomatotropism causing it is rarely considered until the diabetes becomes difficult to control. In cats with difficult to control diabetes mellitus, hypersomatotropism should be considered as a cause only after exclusion of other conditions that can impact insulin.
Gestational diabetes, which occurs in humans and dogs, has never been found in cats. [2] Insulin resistance and diabetes in cats can also have a component of hypersomatotropism (an excess of growth hormone, also leading to acromegaly) [3] and hyperadrenocorticism. [4] In some cats, cancer causes the loss of pancreatic islets. [3]
Most cataracts in dogs are caused by a genetic predisposition, but diabetes mellitus is also a common cause. [65] The only effective treatment is surgical removal. [66] Lens luxation is a displacement of the lens from its normal position. Terrier breeds are predisposed. [63] Nuclear sclerosis is a consistent finding in dogs greater than seven ...
Diabetes mellitus, Cushing's syndrome, Addison's disease, and hypothyroidism are the most common endocrine diseases. Immune-mediated hemolytic anemia is a devastating disease that causes severe anemia in dogs through red blood cell destruction by the immune system.
Domestic cats are affected by over 250 naturally occurring hereditary disorders, many of which are similar to those in humans, such as diabetes, hemophilia and Tay–Sachs disease. [72] [73] For example, Abyssinian cat's pedigree contains a genetic mutation that causes retinitis pigmentosa, which also affects humans. [73]
Cat genetics describes the study of inheritance as it occurs in domestic cats. In feline husbandry, it can predict established traits ( phenotypes ) of the offspring of particular crosses. In medical genetics , cat models are occasionally used to discover the function of homologous human disease genes.
The thrifty gene hypothesis, or Gianfranco's hypothesis [citation needed] is an attempt by geneticist James V. Neel to explain why certain populations and subpopulations in the modern day are prone to diabetes mellitus type 2. He proposed the hypothesis in 1962 to resolve a fundamental problem: diabetes is clearly a very harmful medical ...