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  2. Antimicrobial peptides - Wikipedia

    en.wikipedia.org/wiki/Antimicrobial_peptides

    Some antimicrobial peptides kill both bacteria and fungi, e.g., psoriasin kills E. coli and several filamentous fungi. [12] The cytoplasmic membrane is a frequent target, but peptides may also interfere with DNA and protein synthesis, protein folding, and cell wall synthesis. [10]

  3. Peptidoglycan - Wikipedia

    en.wikipedia.org/wiki/Peptidoglycan

    The peptide chain can be cross-linked to the peptide chain of another strand forming the 3D mesh-like layer. [1] [2] Peptidoglycan serves a structural role in the bacterial cell wall, giving structural strength, as well as counteracting the osmotic pressure of the cytoplasm. This repetitive linking results in a dense peptidoglycan layer which ...

  4. Nonribosomal peptide - Wikipedia

    en.wikipedia.org/wiki/Nonribosomal_peptide

    Nonribosomal peptides (NRP) are a class of peptide secondary metabolites, usually produced by microorganisms like bacteria and fungi. Nonribosomal peptides are also found in higher organisms, such as nudibranchs , but are thought to be made by bacteria inside these organisms. [ 1 ]

  5. Lipopeptide - Wikipedia

    en.wikipedia.org/wiki/Lipopeptide

    A lipopeptide is a molecule consisting of a lipid connected to a peptide. [1] They are able to self-assemble into different structures. [1] [2] [3] Many bacteria produce these molecules as a part of their metabolism, especially those of the genus Bacillus, Pseudomonas and Streptomyces. [4] Certain lipopeptides are used as antibiotics.

  6. Ribosomally synthesized and post-translationally modified ...

    en.wikipedia.org/wiki/Ribosomally_synthesized...

    Bacterial Head-to-Tail Cyclized Peptides refers exclusively to ribosomally synthesized peptides with 35-70 residues and a peptide bond between the N- and C-termini, sometimes referred to as bacteriocins, although this term is used more broadly. The distinctive nature of this class is not only the relatively large size of the natural products ...

  7. Competence stimulating peptide - Wikipedia

    en.wikipedia.org/wiki/Competence_stimulating_peptide

    Competence is the ability of bacteria to pull DNA fragments from the environment and integrate it into their chromosome. Competence stimulating peptides (CSP) are a 17-amino acid signal peptide that triggers quorum sensing, which aids competence, biofilm formation, and virulence.

  8. DD-Transpeptidase - Wikipedia

    en.wikipedia.org/wiki/DD-transpeptidase

    It is involved in bacterial cell wall biosynthesis, namely, the transpeptidation that crosslinks the peptide side chains of peptidoglycan strands. [3] The antibiotic penicillin irreversibly binds to and inhibits the activity of the transpeptidase enzyme by forming a highly stable penicilloyl-enzyme intermediate. [4]

  9. Polypeptide antibiotic - Wikipedia

    en.wikipedia.org/wiki/Polypeptide_antibiotic

    Bacitracin is a polypeptide antibiotic derived from a bacterium, Bacillus subtilis, and acts against bacteria through the inhibition of cell wall synthesis. [6] It does this by inhibiting the removal of phosphate from lipid compounds, thus deactivating its function to transport peptidoglycan; the main component of bacterial cell membranes, to the microbial cell wall.

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