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The shifts in the oral microbiome through time have significant implications for modern health. The current lack of diversity in the oral microbiome makes it more susceptible to imbalances and pathogenic invasions. This, in turn, can lead to a range of oral and systemic health issues, from dental caries to cardiovascular disease.
The relationship between oral microbiota and its human host has changed and this transition can directly be linked to common diseases in human evolutionary past. [3] Evolutionary medicine provides a framework for reevaluating oral health and disease and biological anthropology provides the context to identify the ancestral human microbiome. [1]
The oral microbiota consists of all the microorganisms that exist in the mouth. It is the second largest of the human body and made of various bacteria, viruses, fungi and protozoa. [14] These organisms play an important role in oral and overall health. Anthony Van Leeuwenhoek was the first to view these organisms using a microscope he created ...
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The nitrate-nitrite-nitric oxide pathway is an important mechanism linking the oral microbiome to cardiovascular health”. The authors note that regular use of Listerine should be used with ...
The human microbiome is the aggregate of all microbiota that reside on or within human tissues and biofluids along with the corresponding anatomical sites in which they reside, [1] [2] including the gastrointestinal tract, skin, mammary glands, seminal fluid, uterus, ovarian follicles, lung, saliva, oral mucosa, conjunctiva, and the biliary tract.
Teeth, saliva, and oral tissues are the major components of the oral environment in which the oral microbiome resides. Like most environments, some oral environments, such as teeth and saliva, are abiotic (non-living), and some are living, such as the host immune system or host mouth mucosal tissues- including gums, cheek ("buccal") and tongue (when present).
The Human Microbiome Project (HMP) was a United States National Institutes of Health (NIH) research initiative to improve understanding of the microbiota involved in human health and disease. Launched in 2007, [ 1 ] the first phase (HMP1) focused on identifying and characterizing human microbiota.
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