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Papillary renal cell carcinoma (PRCC) is a malignant, heterogeneous tumor originating from renal tubular epithelial cells of the kidney, which comprises approximately 10-15% of all kidney neoplasms. [1] Based on its morphological features, PRCC can be classified into two main subtypes, which are type 1 and type 2 (eosinophilic). [2]
Metanephric adenoma (MA) is a rare, benign tumour of the kidney, that can have a microscopic appearance similar to a nephroblastoma (Wilms tumours), [1] or a papillary renal cell carcinoma. It should not be confused with the pathologically unrelated, yet similar sounding, mesonephric adenoma .
Collecting duct carcinoma (CDC) is a type of kidney cancer that originates in the papillary duct of the kidney. It is rare, accounting for 1-3% of all kidney cancers. [ 2 ] It is also recently described; a 2002 review found just 40 case reports worldwide. [ 3 ]
The renal cell carcinoma tends to be of the papillary (type 2) form and tends to occur more commonly in women than men with this syndrome. These cancers present earlier than is usual for renal cell carcinomas (typically in the twenties and thirties) and tend to be at relatively advanced stages at presentation.
Psammoma bodies are commonly seen in certain tumors such as: Papillary thyroid carcinoma [2]; Papillary renal cell carcinoma [3]; Ovarian papillary serous cystadenoma and cystadenocarcinoma [4]
Several morphological variants have been described, as the ‘‘mucin-poor variants’’, showing a predominance of tubular or spindle cell components and only minimal pale mucinous background. Focal papillations or papillary cores and foamy histiocytes can also be seen, creating confusion with papillary RCC. Helpful features for diagnosis ...
Clear cell papillary renal cell carcinoma (CCPRCC) is a rare subtype of renal cell carcinoma (RCC) that has microscopic morphologic features of papillary renal cell carcinoma and clear cell renal cell carcinoma, yet is pathologically distinct based on molecular changes and immunohistochemistry.
In both male and female children, renal tumors represent 2% to 6% of kidney cancer, with Wilms' tumor [14] being the most common. Sex. The incidence of kidney cancer is two times greater in men than in women, and this is thought to be due to biological differences. Mortality rates typically decrease more rapidly in women compared to men. [12]