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Overall, they found that females diagnosed with autism or another neurodevelopmental disorder had a greater number of harmful mutations throughout the genome than did males with the same disorders. [20] Women with an extra X chromosome, 47,XXX or triple X syndrome, have autism-like social impairments in 32% of cases. [21]
Process for screening and diagnosing ASD; M-CHAT is Modified Checklist for Autism in Toddlers; (+) is positive test result; (−) is negative test result. There are several factors that make autism spectrum disorder difficult to diagnose. First off, there are no standardized imaging, molecular or genetic tests that can be used to diagnose ASD. [4]
Parents of 1,150 primary school aged children were sent the CAST questionnaire, with 199 responders and 174 taking part in the full data analysis. The results suggested that, compared to other screening tools currently available, the CAST may be useful for identifying children at risk for autism spectrum disorders, in a mainstream non-clinical sample.
The Autism Diagnostic Observation Schedule (ADOS) is a standardized diagnostic test for assessing autism spectrum disorder.The protocol consists of a series of structured and semi-structured tasks that involve social interaction between the examiner and the person under assessment.
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The autism-spectrum quotient (AQ) is a questionnaire published in 2001 by Simon Baron-Cohen and his colleagues at the Autism Research Centre in Cambridge, UK.Consisting of fifty questions, it aims to investigate whether adults of average intelligence (defined as an IQ of 80 or higher by the questionnaire) have symptoms of autism spectrum conditions. [1]
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The Ritvo Autism & Asperger Diagnostic Scale (RAADS) is a psychological self-rating scale developed by Riva Ariella Ritvo (NPI UCLA and CSC Yale). An abridged and translated 14 question version was then developed at the Department of Clinical Neuroscience at the Karolinska Institute, to aid in the identification of patients who may have undiagnosed ASD.