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The table shown on the right can be used in a two-sample t-test to estimate the sample sizes of an experimental group and a control group that are of equal size, that is, the total number of individuals in the trial is twice that of the number given, and the desired significance level is 0.05. [4]
Matched or independent study designs may be used. Power, sample size, and the detectable alternative hypothesis are interrelated. The user specifies any two of these three quantities and the program derives the third. A description of each calculation, written in English, is generated and may be copied into the user's documents.
nQuery is a clinical trial design platform used for the design and monitoring of adaptive, group sequential, and fixed sample size trials. It is most commonly used by biostatisticians to calculate sample size and statistical power for adaptive clinical trial design. nQuery is proprietary software developed and distributed by Statsols. The ...
Lehr's [3] [4] (rough) rule of thumb says that the sample size (for each group) for the common case of a two-sided two-sample t-test with power 80% (=) and significance level = should be: , where is an estimate of the population variance and = the to-be-detected difference in the mean values of both samples.
where N is the population size, n is the sample size, m x is the mean of the x variate and s x 2 and s y 2 are the sample variances of the x and y variates respectively. These versions differ only in the factor in the denominator (N - 1). For a large N the difference is negligible.
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If the sample size is 1,000, then the effective sample size will be 500. It means that the variance of the weighted mean based on 1,000 samples will be the same as that of a simple mean based on 500 samples obtained using a simple random sample.
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