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Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). [12] It has also been given topically (on the skin) for actinic keratoses, skin cancers and Bowen's disease [12] (a type of cutaneous squamous-cell carcinoma), and as eye drops for treatment of ocular surface squamous neoplasia. [13]
Topical 5-fluorouracil (5-FU, Efudex, Carac) has been shown to be an effective therapy for diffuse, but minor actinic cheilitis. 5-fluorouracil works by blocking DNA synthesis. Cells that are rapidly growing need more DNA, so they accumulate more 5-fluorouracil, resulting in their death. Normal skin is much less affected.
The skin membrane is the area (A) for the topical drug molecules to travel across. The skin membrane thickness is known as (h) in the expression, and it determines the diffusion path length. [4] The (C) is the concentration of the diffusing substance across the skin layers and the (D) is the diffusion coefficient.
Topical chemotherapies, such as 5-fluorouracil, are used to treat some cases of non-melanoma skin cancer. [ 74 ] If the cancer has central nervous system involvement, or with meningeal disease, intrathecal chemotherapy may be administered.
Seborrheic dermatitis is a skin condition that causes inflamed, scaly patches of skin on the scalp and face, the American Academy of Dermatology explains. These patches are typically itchy, red ...
The use of a chemotherapeutic agent such as 5-Fluorouracil or imiquimod can prevent the development of skin cancer. It is usually recommended to individuals with extensive sun damage, history of multiple skin cancers, or rudimentary forms of cancer (i.e., solar keratosis). [39]
Skin cancer has been on the rise in the U.S. for years, with 1 in 5 people developing the disease by age 70, according to the Skin Cancer Foundation. But there’s an easy and powerful tool that ...
This page was last edited on 28 April 2005, at 06:27 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may ...
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