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The analytical (total) concentration of a reactant R at the i th titration point is given by = + [] + where R 0 is the initial amount of R in the titration vessel, v 0 is the initial volume, [R] is the concentration of R in the burette and v i is the volume added. The burette concentration of a reactant not present in the burette is taken to be ...
The dissociation constant has molar units (M) and corresponds to the ligand concentration [] at which half of the proteins are occupied at equilibrium, [6] i.e., the concentration of ligand at which the concentration of protein with ligand bound [] equals the concentration of protein with no ligand bound []. The smaller the dissociation ...
In biochemistry, steady state refers to the maintenance of constant internal concentrations of molecules and ions in the cells and organs of living systems. [1] Living organisms remain at a dynamic steady state where their internal composition at both cellular and gross levels are relatively constant, but different from equilibrium concentrations. [1]
In biochemistry, control coefficients [1] are used to describe how much influence a given reaction step has on the flux or concentration of the species at steady state.This can be accomplished experimentally by changing the expression level of a given enzyme and measuring the resulting changes in flux and metabolite levels.
The horizontal axis is the concentration of the ligand. As the Hill coefficient is increased, the saturation curve becomes steeper. In biochemistry and pharmacology, the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration.
A control coefficient [10] [11] [12] measures the relative steady state change in a system variable, e.g. pathway flux (J) or metabolite concentration (S), in response to a relative change in a parameter, e.g. enzyme activity or the steady-state rate of step . The two main control coefficients are the flux and concentration control coefficients.
The Goldman–Hodgkin–Katz voltage equation, sometimes called the Goldman equation, is used in cell membrane physiology to determine the resting potential across a cell's membrane, taking into account all of the ions that are permeant through that membrane.
The binding constant, or affinity constant/association constant, is a special case of the equilibrium constant K, [1] and is the inverse of the dissociation constant. [2] It is associated with the binding and unbinding reaction of receptor (R) and ligand (L) molecules, which is formalized as: R + L ⇌ RL