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The herbal "incense" product was determined to be a synthetic cannabinoid called AMB-FUBINACA. [ 105 ] Since March 2018, Illinois, Wisconsin, Maryland, and 8 other states in the United States have had an outbreak of severe bleeding caused by a synthetic cannabinoid contaminated with brodifacoum , a rat poison that causes bleeding.
More than half a dozen countries had banned herbal blends containing synthetic cannabinoids as of 2010 and many others were also considering banning them. [8] In the US, the states of Kansas, Georgia, Alabama, Tennessee, Missouri, Louisiana, Mississippi, Arkansas, and New York banned K2, herbal incense.
Cannabinoids and their K i values [a]; Name Class K i / nM at CB 1 K i / nM at CB 2 Selectivity Structure JWH-004: Naphthoylindole: 48 ± 13: 4 ± 1.5: CB 2 (12x): JWH-007 [5]: Naphthoylindole: 9.5 ± 4.5
Spice, a synthetic marijuana that was once classified as a "legal high" until it was outlawed in April 2016, and now street dealers are distributing it according to various local reports.
JWH-018, a potent synthetic cannabinoid agonist discovered by John W. Huffman at Clemson University. It was often sold in legal smoke blends collectively known as "spice". Several countries and states have moved to ban it legally. JWH-073; CP-55940, produced in 1974, this synthetic cannabinoid receptor agonist is many times more potent than THC.
JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
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5F-ADB (also known as MDMB-5F-PINACA [2] and 5F-MDMB-PINACA) is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family, which has been used as an active ingredient in synthetic cannabis products and has been sold online as a designer drug.