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The following is a list of chemicals published as a requirement of Safe Drinking Water and Toxic Enforcement Act of 1986, commonly known as California Proposition 65, that are "known to the state to cause cancer or reproductive toxicity" as of January 3, 2020. [1]
Sodium phosphates are popular in commerce in part because they are inexpensive and because they are nontoxic at normal levels of consumption. [4] However, oral sodium phosphates when taken at high doses for bowel preparation for colonoscopy may in some individuals carry a risk of kidney injury under the form of phosphate nephropathy.
Sodium phosphates including monosodium phosphate, disodium phosphate, and trisodium phosphate are approved as food additives in the EU. They are commonly used as acidity regulators and have the collective E number E339. [11] The United States Food and Drug Administration lists sodium phosphates as generally recognized as safe. [12] [13]
A cancer syndrome or family cancer syndrome is a genetic disorder in which inherited genetic mutations in one or more genes predisposes the affected individuals to the development of cancers and may also cause the early onset of these cancers. Although cancer syndromes exhibit an increased risk of cancer, the risk varies.
Butylphenyl diphenyl phosphate and propylphenyl diphenyl phosphate became available after 1960. [ 79 ] In addition to their use as hydraulic base-stock, organophosphates (tricresyl phosphate) and metal organothiophosphates ( zinc dithiophosphate ) are used as both an antiwear additives and extreme pressure additives in lubricants , where they ...
Hyperphosphatemia causes acute kidney injury in tumor lysis syndrome, because of deposition of calcium phosphate crystals in the kidney parenchyma. [2] Hypocalcemia. Because of the hyperphosphatemia, calcium is precipitated to form calcium phosphate, leading to hypocalcemia. [2] Symptoms of hypocalcemia include (but are not limited to): [9] tetany
The diagnosis of hyperphosphatemia is made through measuring the concentration of phosphate in the blood. A phosphate concentration greater than 1.46 mmol/L (4.5 mg/dL) is indicative of hyperphosphatemia, though further tests may be needed to identify the underlying cause of the elevated phosphate levels. [5]
A study based on sodium butyrate effects on cancer cells conveys that it has an effect on androgen receptor co-regulator expression, transcription activity, and also on histone acetylation in cancer cells. [56] This explains why the addition of sodium butyrate show increased activity of alkaline phosphatase in the cancer cells of the human ...