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A myelodysplastic syndrome (MDS) is one of a group of cancers in which blood cells in the bone marrow do not mature, and as a result, do not develop into healthy blood cells. [3] Early on, no symptoms typically are seen. [3] Later, symptoms may include fatigue, shortness of breath, bleeding disorders, anemia, or frequent infections. [3]
Extreme doses may result in a respiratory depression, coma, or death. [3] Complications may include seizures, aspiration pneumonia, low blood sugar, and injuries or self-harm such as suicide. [3] [4] Alcohol intoxication can lead to alcohol-related crime with perpetrators more likely to be intoxicated than victims. [12]
Alcohol-related brain damage can have drastic effects on the individuals affected and their loved ones. The options for treatment are very limited compared to other disorders. Although limited, most patients with alcohol-related cognitive deficits experienced slight improvement of their symptoms over the first two to three months of treatment. [8]
After binge drinking, unconsciousness can occur and extreme levels of consumption can lead to alcohol poisoning and death (a concentration in the blood stream of 0.40% will kill half of those affected [33] [medical citation needed]). Alcohol may also cause death indirectly, by asphyxiation from vomit.
Alcoholic ketoacidosis (AKA) is a specific group of symptoms and metabolic state related to alcohol use. [3] Symptoms often include abdominal pain, vomiting, agitation, a fast respiratory rate, and a specific "fruity" smell. [2] Consciousness is generally normal. [1] Complications may include sudden death. [1]
The signs and symptoms of alcohol-related dementia are essentially the same as the symptoms present in other types of dementia, making alcohol-related dementia difficult to diagnose. There are very few qualitative differences between alcohol dementia and Alzheimer's disease and it is therefore difficult to distinguish between the two. [6]
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However, there is ongoing debate over the active mechanisms, [6] [7] including whether the main cause is the direct toxic effect of alcohol itself or whether the disease is a result of alcoholism-related malnutrition. [1] A 2019 metastudy found that the relationship between ethanol toxicity and neuropathy remained unproven. [8]