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Myelin basic protein (MBP) is a protein believed [weasel words] to be important in the process of myelination of nerves in the nervous system. The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction . [ 5 ]
Protein content includes myelin basic protein (MBP), [21] which is abundant in the CNS where it plays a critical, non-redundant role in formation of compact myelin; myelin oligodendrocyte glycoprotein (MOG), [22] which is specific to the CNS; and proteolipid protein (PLP), [23] which is the most abundant protein in CNS myelin, but only a minor ...
The basic helix–loop–helix transcription factor OLIG1 plays an integral role in the process of oligodendrocyte myelinogenesis by regulating expression of myelin-related genes. OLIG1 is necessary in order to initiate myelination by oligodendrocytes in the brain, but is somewhat dispensable in the spinal cord.
Myelin P2 protein is a protein that in humans is encoded by the PMP2 gene. [ 5 ] [ 6 ] [ 7 ] Myelin protein P2 is a constituent of peripheral nervous system (PNS) myelin , also present in small amounts in central nervous system (CNS) myelin.
The insulation must be proportional to the diameter of the fibre inside. The optimal ratio of axon diameter divided by the total fiber diameter (which includes the myelin) is 0.6. [24] Oligodendrocytes in rat cerebellum stained with antibody to myelin basic protein in red and for DNA in blue. Two oligodendrocyte cell bodies are clearly visible ...
PLP1 is a critical protein for myelin formation. PMD is classified as a leukodystrophy, meaning that it is a disease affecting the white matter of the brain. Madhavan et al. tested how well their myelinoid system could recapitulate the established cellular pathology of PMD.
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Myelin proteolipid protein (PLP or lipophilin) [1] is the major myelin protein from the central nervous system (CNS). It plays an important role in the formation or ...
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