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The name estradiol derives from estra-, Gk. οἶστρος (oistros, literally meaning "verve or inspiration"), [96] which refers to the estrane steroid ring system, and -diol, a chemical term and suffix indicating that the compound is a type of alcohol bearing two hydroxyl groups.
Estradiol dipropionate, another short-acting ester of estradiol in oil solution for use by intramuscular injection, was marketed under the brand name Di-Ovocylin by 1939. [191] [185] In contrast to estrone, estradiol was never marketed in oil solution for intramuscular injection.
[1] [2] There are three major endogenous estrogens that have estrogenic hormonal activity: estrone (E1), estradiol (E2), and estriol (E3). [1] [3] Estradiol, an estrane, is the most potent and prevalent. [1] Another estrogen called estetrol (E4) is produced only during pregnancy. Estrogens are synthesized in all vertebrates [4] and some insects ...
Compound Chemical name Structure Marketed Estradiol (E2) Estra-1,3,5(10)-triene-3,17β-diol 2-Hydroxyestradiol: 2-Hydroxyestradiol – 4-Hydroxyestradiol
Estrapronicate (estradiol 3-propionate 17β-nicotinate; Trophobolene, Trophoboline) Orestrate (estradiol 3-propionate 17β-(1-cyclohexenyl) ether) The following cytostatic antineoplastic nitrogen mustard esters of estradiol have not been marketed: [2] Alestramustine (estradiol 3-(bis(2-chloroethyl)carbamate), 17-ester with L-alanine)
Estradiol cypionate (Depo-Estradiol, Estradiol Cypionate) – 5 mg/mL (1 mg/mL and 3 mg/mL discontinued) Estradiol valerate (Delestrogen, Estradiol Valerate) – 10 mg/mL, 20 mg/mL, 40 mg/mL; Polyestradiol phosphate (Estradurin) was previously available in the U.S. but was discontinued.