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The thrombus deposits on the ruptured plaque to completely block the coronary artery, halting oxygen supply to cardiomyocytes. Under hypoxia, cardiomyocytes perform anaerobic respiration, producing more lactate. [34] [36] With blocked coronary circulation, lactate clearance from cardiomyocytes is also hindered. [36]
Symptoms include chest pain or angina, shortness of breath, and fatigue. [6]A completely blocked coronary artery will cause a heart attack. [6] Common heart attack symptoms include chest pain or angina, pain or discomfort that spreads to the shoulder, arm, back, neck jaw, teeth or the upper belly, cold sweats, fatigue, heartburn, nausea, shortness of breath, or lightheadedness.
The thrombus then travels downstream to other blood vessels, where the blood clot may partially or completely block blood flow. If the blood flow is completely blocked, cell deaths occur due to the lack of oxygen supply to nearby cells, resulting in necrosis. [81] The narrowing or obstruction of blood flow can occur in any artery within the body.
Clogged arteries, known as arteriosclerosis, can play a significant role in causing several severe heart conditions and instigating major medical emergencies like heart attack and stroke.
The relatively narrow coronary arteries are commonly affected by atherosclerosis and can become blocked, causing angina or a heart attack. The coronary arteries are classified as "terminal circulation", since they represent the only source of blood supply to the myocardium; there is very little redundant blood supply, that is why blockage of ...
Chris Kirmsse's blood pressure was 200/100. Daughter Christine made her go to the ER where Chris learned she had had a heart attack and three blocked arteries.
When someone has a stroke, a blood vessel to the brain bursts or is blocked by a clot. The result: Part of the brain cannot get the oxygen and nutrients it needs from blood, so brain cells die ...
A more severe form is chronic total occlusion (CTO) when a coronary artery is completely obstructed for more than 3 months. [ 65 ] Microvascular angina is a type of angina pectoris in which chest pain and chest discomfort occur without signs of blockages in the larger coronary arteries of their hearts when an angiogram (coronary angiogram) is ...
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