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1-Phenylethylamine is the organic compound with the formula C 6 H 5 CH(NH 2)CH 3. This primary amine is a colorless liquid is often used in chiral resolutions . Like benzylamine , it is relatively basic and forms stable ammonium salts and imines .
1-Phenylethylamine is a methylated benzylamine derivative that is chiral; enantiopure forms are obtained by resolving racemates. Its racemic form is sometimes known as (±)-α-methylbenzylamine. [28] Both benzylamine and 1-phenylethylamine form stable ammonium salts and imines due to their relatively high basicity.
One method for preparing β-phenethylamine, set forth in J. C. Robinson and H. R. Snyder's Organic Syntheses (published 1955), involves the reduction of benzyl cyanide with hydrogen in liquid ammonia, in the presence of a Raney-Nickel catalyst, at a temperature of 130 °C and a pressure of 13.8 MPa. Alternative syntheses are outlined in the ...
Trichocereus macrogonus var. pachanoi, syn. Echinopsis pachanoi contain several phenethylamines.. Naturally occurring phenethylamines are organic compounds which may be thought of as being derived from phenethylamine itself that are found in living organisms.
[1] [25] Additionally, enzyme biocatalysts are often quite selective in reactivity so they can be used in the presence of other functional groups, without the use of protecting groups. [ 24 ] [ 26 ] For instance a class of enzymes called imine reductases , IREDs, can be used to catalyze direct asymmetric reductive amination to form chiral amines.
N-Methylphenethylamine (NMPEA) is a naturally occurring trace amine neuromodulator in humans that is derived from the trace amine, phenethylamine (PEA). [2] [3] It has been detected in human urine (<1 μg over 24 hours) [4] and is produced by phenylethanolamine N-methyltransferase with phenethylamine as a substrate, which significantly increases PEA's effects.
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Substituted phenethylamines (or simply phenethylamines) are a chemical class of organic compounds that are based upon the phenethylamine structure; [note 1] the class is composed of all the derivative compounds of phenethylamine which can be formed by replacing, or substituting, one or more hydrogen atoms in the phenethylamine core structure with substituents.