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However, zaleplon has not been empirically shown to increase total sleep time. [14] [12] Zaleplon does not significantly affect driving performance the morning following bedtime administration or 4 hours after middle-of-the-night administration. [15] It may have advantages over benzodiazepines with fewer adverse effects. [16]
Erythromycin appears to increase the absorption rate of zopiclone and prolong its elimination half-life, leading to increased plasma levels and more pronounced effects. Itraconazole has a similar effect on zopiclone pharmacokinetics as erythromycin.
Common side effects include sedation, fatigue, weight gain, constipation, and dry mouth. [11] Other side effects include low blood pressure with standing, seizures, a prolonged erection, high blood sugar, tardive dyskinesia, and neuroleptic malignant syndrome. [11] In older people with dementia, its use increases the risk of death. [11]
Sleeping pills, including eszopiclone, have been associated with an increased risk of death. [20] Hypersensitivity to eszopiclone is a contraindication to its use. The presence of liver impairment, lactation and activities requiring mental alertness (e.g., driving) may be considered when determining frequency and dosage. [7]
The normal sleep architecture may be altered (REM sleep depression). Trihexyphenidyl may lower the seizure-threshold. Peripheral side effects: dry mouth, impaired sweating, abdominal discomfort, nausea, and constipation are frequent. Tachycardia or heart palpitations (fast heart rate) may be noted. Allergic reactions are rare, but may occur.
These gastrointestinal side effects tend to be more common during the first few weeks of treatment or while the patient adjusts to an increased dose. ... 0.5-milligram and 1-milligram doses of ...
Common side effects include trouble sleeping, anxiety, headache, hallucinations, high blood pressure, fast heart rate, loss of appetite, and urinary retention. [11] Serious side effects include stroke and heart attack. [11] While likely safe in pregnancy, its use in this population is poorly studied. [12] [13] Use during breastfeeding is not ...
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