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The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration. LD 50 figures are frequently used as a general indicator of a substance's acute toxicity. A lower LD 50 is indicative of higher toxicity. The term LD 50 is generally attributed to John William Trevan. [2]
Oral LD 50: Up to and including 50 mg/kg From 50 to 500 mg/kg From 500 to 5000 mg/kg Greater than 5000 mg/kg Inhalation LC50 Up to and including 0.2 mg/L From 0.2 to 2 mg/L From 2. to 20 mg/L Greater than 20 mg/L Dermal LD50 Up to and including 200 mg/kg From 200 to 2000 mg/kg From 2000 to 20,000 mg/kg Greater than 20,000 mg/kg Eye Effects
In toxicology, the lethal dose (LD) is an indication of the lethal toxicity of a given substance or type of radiation.Because resistance varies from one individual to another, the "lethal dose" represents a dose (usually recorded as dose per kilogram of subject body weight) at which a given percentage of subjects will die.
Oral Toxicity: LD 50 for acute oral toxicity means that dose of the material administered to both male and female young adult albino rats which causes death within 14 days in half the animals tested. The number of animals tested must be sufficient to give statistically valid results and be in conformity with good pharmacological practices.
The system is based on LD50 determination in rats, thus an oral solid agent with an LD50 at 5 mg or less/kg bodyweight is Class Ia, at 5–50 mg/kg is Class Ib, LD50 at 50–2000 mg/kg is Class II, and at LD50 at the concentration more than 2000 mg/kg is classified as Class III. Values may differ for liquid oral agents and dermal agents. [1]
Results from Wednesday's forensic autopsy on Pownell are pending toxicology reports, which takes up to eight weeks to get labs returned, Costello said Thursday in a news release.
It is calculated using the LD50 or LC50. [1] The Occupational Safety and Health Administration (OSHA) regulation (1910.134(b)) defines the term as "an atmosphere that poses an immediate threat to life, would cause irreversible adverse health effects, or would impair an individual's ability to escape from a dangerous atmosphere."
The results suggest that bone loss could be an effect of levothyroxine use in older adults, even when used at the appropriate dosage, which could be a concern in terms of osteoporosis risk. Is ...