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In humans, the vermiform appendix is sometimes called a vestigial structure as it has lost much of its ancestral digestive function.. Vestigiality is the retention, during the process of evolution, of genetically determined structures or attributes that have lost some or all of the ancestral function in a given species. [1]
Ileum, caecum and colon of rabbit, showing Appendix vermiformis on fully functional caecum The human vermiform appendix on the vestigial caecum. The appendix was once believed to be a vestige of a redundant organ that in ancestral species had digestive functions, much as it still does in extant species in which intestinal flora hydrolyze cellulose and similar indigestible plant materials. [10]
The appendix, long misunderstood as a vestigial organ, is now recognized as a key MALT structure, playing an essential role in B-lymphocyte-mediated immune responses, hosting extrathymically derived T-lymphocytes, regulating pathogens through its lymphatic vessels, and potentially producing early defenses against diseases. [1]
The longest appendix ever removed was 26 cm (10 in) long. [3] The appendix is usually located in the lower right quadrant of the abdomen, near the right hip bone. The base of the appendix is located 2 cm (0.79 in) beneath the ileocecal valve that separates the large intestine from the small
The human appendix is a vestigial organ thought to serve no purpose. Appendicitis, an infection of this organ, is a certain death without medical intervention. "During the past few years, however, several studies have suggested its immunological importance for the development and preservation of the intestinal immune system." [11]
Peyer's patches (or aggregated lymphoid nodules) are organized lymphoid follicles, named after the 17th-century Swiss anatomist Johann Conrad Peyer. [1] They are an important part of gut associated lymphoid tissue usually found in humans in the lowest portion of the small intestine, mainly in the distal jejunum and the ileum, but also could be detected in the duodenum.
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If a structure was once called vestigial, but is now known to be functional, then calling it "Functioning Vestigial Structures" violates the definition of vestigial, because by definition, it is not vestigial. It was previously called vestigial, but that was a mistake. It is not correct to call the vermiform appendix vestigial.