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  2. Phenytoin - Wikipedia

    en.wikipedia.org/wiki/Phenytoin

    Phenytoin may accumulate in the cerebral cortex over long periods of time which can cause atrophy of the cerebellum. The degree of atrophy is related to the duration of phenytoin treatment and is not related to dosage of the medication. [23] Phenytoin is known to be a causal factor in the development of peripheral neuropathy. [24]

  3. Therapeutic index - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_index

    The therapeutic window (or pharmaceutical window) of a drug is the range of drug dosages which can treat disease effectively without having toxic effects. [18] Medication with a small therapeutic window must be administered with care and control, frequently measuring blood concentration of the drug, to avoid harm.

  4. Dose-ranging study - Wikipedia

    en.wikipedia.org/wiki/Dose-ranging_study

    The maximum tolerable dose (MTD) information is necessary to be able to design such groups and therefore dose-ranging studies are usually designed after the availability of MTD information. [1] The main goal of a dose-ranging study is to estimate the response vs. dose given, so as to analyze the efficacy and safety of the drug.

  5. Anticonvulsant - Wikipedia

    en.wikipedia.org/wiki/Anticonvulsant

    The risk of major congenital malformations for children exposed to these ASMs were within the range for children who were not exposed to any ASMs during pregnancy. [100] People with epilepsy can have healthy pregnancies and healthy babies. However, proper planning and care is essential to minimize the risk of congenital malformations or adverse ...

  6. Your Guide to the 6 Most Common Types of Depression ... - AOL

    www.aol.com/6-types-depression-medications...

    As far as side effects go, there’s a range. But one 2016 review suggests that paroxetine may be one of the least safe antidepressants. ... The starting dose is usually 75 milligrams, but it can ...

  7. Primidone - Wikipedia

    en.wikipedia.org/wiki/Primidone

    The usual dose range is 120 to 250 mg/day in two divided doses or as one single dose. ... Like phenytoin, primidone is rarely associated with lymphadenopathy. [50]

  8. Are Wellbutrin Dosages Different For Anxiety And Depression?

    www.aol.com/wellbutrin-dosages-different-anxiety...

    The Wellbutrin dosage range for depression can be between 75 mg and 150 mg per single dose, depending on your needs. ... but it can be increased to a maximum safe dose of 225 milligrams daily.

  9. Isoniazid - Wikipedia

    en.wikipedia.org/wiki/Isoniazid

    Isoniazid may increase the amount of phenytoin in the body. The doses of phenytoin may need to be adjusted when given with isoniazid. [40] [41] Isoniazid may increase the plasma levels of theophylline. There are some cases of theophylline slowing down isoniazid elimination. Both theophylline and isoniazid levels should be monitored. [42]