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Anticholinergics generally have antisialagogue effects (decreasing saliva production), and most produce some level of sedation, both being advantageous in surgical procedures. [8] [9] Until the beginning of the 20th century, anticholinergic drugs were widely used to treat psychiatric disorders. [10]
Doxylamine is also a potent anticholinergic, meaning that it causes delirum at high doses—i.e., at much higher doses than recommended. [8] (Specifically it is an antagonist of the muscarinic acetylcholine receptors M 1 through M 5.) These sedative and deliriant effects have in some cases led to using the drug recreationally.
Combined use of medications with anticholinergics may cause synergistic (supra-additive), additive, or antagonistic interactions, leading to no therapeutic effect or overdosing. [25] [26] Below listed are some medications or food that can interact with anticholinergics. Medications indicated for: Irregular heartbeat, e.g. disopyramide ...
A fungus that lives on specific grains produces ergot alkaloids, of which ergotamine tartrate is a synthetic derivative. Barbiturate phenobarbital is an anticonvulsive and sedative drugs. Three active components cooperate to alleviate menopausal symptoms. The belladonna alkaloids which is an anticholinergic drug acting on the autonomic nervous ...
Diphenhydramine is contraindicated in premature infants and neonates, as well as people who are breastfeeding. It is a pregnancy Category B drug. Diphenhydramine has additive effects with alcohol and other CNS depressants. Monoamine oxidase inhibitors prolong and intensify the anticholinergic effect of antihistamines. [47]
"Given all the research evidence, physicians might want to consider alternatives to anticholinergic medications, if available, when working with older patients," a researcher told CNN.
Oxybutynin, sold under the brand name Ditropan among others, is an anticholinergic medication primarily used to treat overactive bladder.It is widely considered a first-line therapy for overactive bladder due to its well-studied side effect profile, broad applicability, and continued efficacy over long periods of time.
The study authors reported that for people younger than 60, 65% of women and 79% of men received cholesterol-lowering medication after diagnosis. Three years later, 52% of women and 78% of men ...
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