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Insulin glargine sold under the brand name Lantus among others is a long-acting modified form of medical insulin, used in the management of type 1 and type 2 diabetes. [7] It is injected just under the skin . [ 7 ]
[1] [5] The basal level of insulin may be maintained for up to 20 hours, but the time is affected by the size of the injected dose. The changes are: removal of B30 threonine, attachment of a myristic acid tail to the B29 lysine's "tail" nitrogen. As a result, this insulin binds to serum albumin with high affinity, increasing its duration of ...
Prandial insulin, also called mealtime or bolus insulin, is designed as a bolus dose of insulin prior to a meal to regulate the spike in blood glucose that occurs following a meal. The dose of prandial insulin may be static, or may be calculated by the patient using either their current blood sugar, planned carbohydrate intake, or both.
Sanofi's Lantus is the globe's best selling diabetes drug, generating more than $7.5 billion in revenue last year. Lantus makes up 17% of Sanofi's global sales and has posted two consecutive years ...
The higher concentrations are used to lessen the volume of the injection, and allow the same dose of insulin to be injected with less force. [10] In some cases, these medications may be combined into one pen to be administered daily, for example insulin degludec with liraglutide [6] and insulin glargine with lixisenatide. [11]
The area under the effect curve (AUEC) is an integral of the effect of a drug over time, estimated as a previously-established function of concentration. It was proposed to be used instead of AUC in animal-to-human dose translation, as computer simulation shows that it could cope better with half-life and dosing
Image credits: Bored Panda #2 Dave Grohl Fathered A Baby Girl Outside Of His Marriage. Lead singer of the Foo Fighters Dave Grohl isn’t trying to hide his truth. Back in September, the musician ...
Absorption is the journey of a drug travelling from the site of administration to the site of action. [ 1 ] [ 2 ] The drug travels by some route of administration ( oral , topical-dermal , etc.) in a chosen dosage form (e.g., tablets , capsules , or in solution ). [ 3 ]
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261