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In humans, the pigmentation of the iris varies from light brown to black, depending on the concentration of melanin in the iris pigment epithelium (located on the back of the iris), the melanin content within the iris stroma (located at the front of the iris), and the cellular density of the stroma. [4]
The original Martin scale, summarized below, consists of 16 colors (from light blue to dark brown-black) that correspond to the different eye colors observed in nature due to the amount of melanin in the iris. The numbering is reversed in order to match the Martin–Schultz scale, which is still used in biological anthropology. In this case ...
The scale consists of 20 colors [1] (from light blue to dark brown-black) that correspond to the different eye colors observed in nature due to the amount of melanin in the iris (in this case, the lower the number, the lighter the eye color): [2] [3] 1-2: blue iris (1a, 1b, 1c, 2a : light blue iris - 2b: darker blue iris) 3: blue-gray iris
Melanin is yellowish to dark hazel in the stromal pigment cells, and black in the iris pigment epithelium, which lies in a thin but very opaque layer across the back of the iris. Most human irises also show a condensation of the brownish stromal melanin in the thin anterior border layer, which by its position has an overt influence on the ...
The stroma around the iris sphincter muscle becomes darker than the peripheral stroma. [medical citation needed] A stimulation of melanin synthesis within iris melanocytes has been postulated. [21] Neoplasm – Nevi and melanomatous tumors. Iridocorneal endothelium syndrome [3] Iris ectropion syndrome [3] [22]
Melanin (/ ˈ m ɛ l ə n ɪ n / ⓘ; from Ancient Greek μέλας (mélas) 'black, dark') is a family of biomolecules organized as oligomers or polymers, which among other functions provide the pigments of many organisms. [1] Melanin pigments are produced in a specialized group of cells known as melanocytes.
The iris pigment epithelium (IPE) is a one cell thick layer of cuboidal cells lying behind the iris. The epithelial cells are highly pigmented due to the numerous large melanosomes which pack the cytoplasm of each cell. Towards the central axis, the IPE terminates at the pupillary margin.
The key enzyme in melanin synthesis is tyrosinase. When this protein is defective, no melanin can be generated resulting in certain types of albinism. In some amphibian species there are other pigments packaged alongside eumelanin. For example, a novel deep (wine) red-colour pigment was identified in the melanophores of phyllomedusine frogs. [13]