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Donepezil, sold under the brand name Aricept among others, is a medication used to treat dementia of the Alzheimer's type. [ 3 ] [ 4 ] [ 8 ] It appears to result in a small benefit in mental function and ability to function. [ 9 ]
Memantine/donepezil, sold under the brand name Namzaric among others, is a fixed dose combination medication used for the treatment of dementia of the Alzheimer's type. [1] It contains memantine , as the hydrochloride, a NMDA receptor antagonist ; and donepezil as the hydrochloride, an acetylcholinesterase inhibitor . [ 1 ]
Memantine when added to donepezil in those with moderate-to-severe dementia resulted in "limited improvements" in a 2017 review. [24] The UK National Institute for Clinical Excellence (NICE) issued guidance in 2018 recommending consideration of the combination of memantine with donepezil in those with moderate-to-severe dementia.
Donepezil by Pfizer (NYSE:PFE), Rivastigmine by Novartis (NYSE:NVS), and Galantamine by Johnson & Johnson (NYSE:JNJ) are among the FDA approved drugs treat Alzheimer's, a type of dementia.
ATC code N06 Psychoanaleptics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Sugimoto was born as the eighth child among nine children in a downtown section of Tokyo in 1943, and joined Eisai, a Japanese pharmaceutical company. [3] While working for Eisai, he graduated from Chuo University in 1969 and obtained his doctorate in pharmacology at Hiroshima University in 2002. [3]
In fact, the Scientific Report of the 2025 Dietary Guidelines Advisory Committee is recommending that people start with eating beans, peas, and lentils before meat.
Paraoxon and rivastigmine are both acetylcholinesterase inhibitors and butyrylcholinesterase inhibitors. [14] [11] [7]In 2015, the United States Food and Drug Administration's Adverse Event Reporting System database compared rivastigmine to the other ChEI drugs donepezil and galantamine found that rivastigmine was associated with a higher frequency of reports of death as an adverse event.
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