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Dorzolamide/timolol, sold under the brand name Cosopt among others, is a medication used to treat high pressure inside the eye including glaucoma. [3] [5] [6] It is a combination of dorzolamide hydrochloride and timolol maleate. [3] It may be used when a beta blocker, like timolol, is not sufficient alone. [7] It is used as an eye drop. [3]
Timolol can also lead to fainting, congestive heart failure, depression, confusion, worsening of Raynaud's syndrome and impotence. [23] Side effects when given in the eye include: burning sensation, eye redness, superficial punctate keratopathy, corneal numbness. [25] [14]
Side effects in less than 10% of people include other eye problems such as itching, foreign body sensation or dry eye, as headache or hyperpigmentation (darkening) of the skin around the eye. [ 4 ] Hyperpigmentation is an adverse effect of bimatoprost, [ 5 ] while the others are fairly common for eye drops in general.
Effects begin within three hours and last for at least eight hours. [3] It is also available as the combination dorzolamide/timolol. [3] [4] Common side effects include eye discomfort, eye redness, taste changes, and blurry vision. [3] Serious side effects include Steven Johnson syndrome. [3] Those allergic to sulfonamides may be allergic to ...
Travoprost/timolol, sold under the brand name Duotrav among others, ... "Timolol maleate mixture with Travoprost". Drug Information Portal. U.S. National Library of ...
[4] [5] It is also available in the fixed-dose combination medication brimonidine/timolol along with timolol maleate. [6] Common side effects when used in the eyes include itchiness, redness, and a dry mouth. [4] Common side effects when used on the skin include redness, burning, and headaches. [5]
Brimonidine/timolol, sold under the brand name Combigan among others, is a fixed-dose combination medication eye drop used for the treatment of glaucoma. [1] It is a combination of brimonidine (an α 2 adrenergic agonist) and timolol (a β adrenergic blocker).
While definitive sites of metabolism have not been firmly established, there are several metabolites worthy of note. N-Desethylbrinzolamide is an active metabolite of the parent compound, and thus exhibits carbonic anhydrase inhibitory activity (largely carbonic anhydrase-I, when in the presence of Brinzolamide) and also accumulates in the erythrocytes.