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Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. [ 4 ] [ 5 ] [ 6 ] IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with a length of 1.4kb. [ 4 ] It has a mass of 13 kDa and folds into 4 alpha helical bundles. [ 7 ]
Tocilizumab, sold under the brand name Actemra among others, is an immunosuppressive drug, used for the treatment of rheumatoid arthritis, systemic juvenile idiopathic arthritis, polyarticular juvenile idiopathic arthritis, giant cell arteritis, cytokine release syndrome, COVID‑19, and systemic sclerosis-associated interstitial lung disease (SSc-ILD).
The most common side effects include injection site reactions, dry eye and conjunctivitis (redness and discomfort in the eye) including allergic conjunctivitis. [ 8 ] Lebrikizumab was approved for medical use in the European Union in November 2023, [ 8 ] in Canada in June 2024, [ 5 ] and in the United States in September 2024 to treat moderate ...
Although it is a structural analogue of tacrolimus, it acts somewhat differently and has different side-effects. Contrary to ciclosporin and tacrolimus, drugs that affect the first phase of T lymphocyte activation, sirolimus affects the second phase, namely signal transduction and lymphocyte clonal proliferation.
Tozorakimab (formerly MEDI 3506) is a monoclonal antibody against interleukin-33 (IL-33) that works via RAGE and epidermal growth factor receptors. [1] [2] [3] [4]
Tralokinumab is indicated for the treatment of moderate-to-severe atopic dermatitis in adults who are candidates for systemic therapy. [5] [3]In the United States, tralokinumab is indicated for the treatment of moderate-to-severe atopic dermatitis in adults whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.
Vitamin D and Calcium supplementation may reduce risk of cancer but increase risk of cardiovascular disease, new research shows. Experts explain. Taking These Supplements May Reduce Your Cancer ...
Anti-interleukin-6 agents are a class of therapeutics. Interleukin 6 is a cytokine relevant to many inflammatory diseases and many cancers. [ 1 ] Hence, anti-IL6 agents have been sought.