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Several groups of drugs slow conduction through the heart, without actually preventing an arrhythmia. These drugs can be used to "rate control" a fast rhythm and make it physically tolerable for the patient. [citation needed] Some arrhythmias promote blood clotting within the heart and increase the risk of embolus and stroke.
Two distinct drug classes in which cardiotoxicity can occur are in anti-cancer and antiarrhythmic drugs. Anti-cancer drug classes that cause cardiotoxicity include anthracyclines, monoclonal antibodies, and antimetabolites. This form generally manifests as a progressive form of heart failure, but can also manifest as an harmful arrhythmia. [2]
Parasystole is a kind of arrhythmia caused by the presence and function of a secondary pacemaker in the heart, which works in parallel with the SA node. Parasystolic pacemakers are protected from depolarization by the SA node by some kind of entrance block. This block can be complete or incomplete.
Mexiletine has several uses including the treatment of abnormal heart rhythms or arrhythmias, chronic pain, and myotonia. In general when treating arrhythmias, mexiletine is reserved for use in dangerous heart rhythm disturbances such as ventricular tachycardia. [3] It is of particular use when treating arrhythmias caused by long QT syndrome. [4]
The most common underlying causes are different, depending on the patient's age. Common cardiac causes include coronary artery disease, non-atherosclerotic coronary artery abnormalities, structural heart damage, and inherited arrhythmias. Common non-cardiac causes include respiratory arrest, diabetes, medications, and trauma.
Risk of fatal cardiac arrhythmias [2] Clioquinol: 1973 France, Germany, UK, US Neurotoxicity. [3] Clobutinol: 2007 Germany Ventricular arrhythmia, QT-prolongation. [14] Cloforex: 1969 Germany Cardiovascular toxicity. [3] Clomacron: 1982 UK Hepatotoxicity. [3] Clometacin: 1987 France Hepatotoxicity. [3] Co-proxamol (Distalgesic) 2004 UK Risk of ...
Ectopic atrial tachycardia (EAT), also known as automatic atrial tachycardia, is an arrhythmia caused by both atria with abnormally fast atrial rates. [12] The ectopic focus's firing rate is quicker than that of the sinus node, and it overrides normal sinus node activity. Heart rates in children and adolescents can range from 130 to 210 beats ...
It presents the drugs on two axes, instead of one, and is presented in tabular form. On the Y axis, each drug is listed, in roughly the Singh-Vaughan Williams order. On the X axis, the channels, receptors, pumps, and clinical effects are listed for each drug, with the results listed in a grid.