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Credé prophylaxis is the practice of washing a newborn's eyes with a 2% silver nitrate solution to protect against neonatal conjunctivitis caused by Neisseria gonorrhoeae, thereby preventing blindness. [1] The Credé procedure was developed by the German physician Carl Siegmund Franz Credé who implemented it in his hospital in Leipzig in 1880 ...
Antibiotic ointment is typically applied to the newborn's eyes within 1 hour of birth as prevention against gonococcal ophthalmia. [3] This may be erythromycin, tetracycline, or rarely silver nitrate [3] or Argyrol (mild silver protein). The use of 1-2% silver nitrate solution was introduced in 1881 by Credé as Credé's prophylaxis. [3] [12 ...
During a three-year period, Credé treated 1160 newborns with silver nitrate, with only 0.15% of the infants developing ophthalmia. [2] The silver nitrate solution is sometimes referred to as "Credé's prophylaxis" in medical literature, and other eyedrop prophylactics (for example, antibiotics) are still called by the same name. Later, the ...
Silver compounds have been used in external preparations as antiseptics, including both silver nitrate and silver proteinate. Before the development of antibiotics, Credé's prophylaxis used a 2% solution of silver nitrate to prevent neonatal conjunctivitis, which used to account for half of all cases of blindness in Europe.
In 1881 Credé introduced a method known as Credé's prophylaxis, which used of dilute (2%) solutions of silver nitrate in newborn babies' eyes at birth to prevent contraction of gonorrhea from the mother, which could cause blindness via ophthalmia neonatorum. (Modern antibiotics are now used instead). [19] [20] [21] [22]
A silver-gelatin colloid, made by the reaction of silver nitrate, sodium hydroxide and gelatin, in which a complex colloidal aggregate is formed, Barnes could rightfully assert Argyrol differed in its chemical assay, for instance, as it was claimed to contain over 30% silver. When compounded in varying strengths, nevertheless Argyrol is silver ...
In the treatment of umbilical granulomas, silver nitrate is applied to the umbilical site to burn off the excess tissue. [18] The absence of nerve endings within the granuloma make this a painless treatment for the newborn. [19] While painless, contact of silver nitrate to the adjacent, healthy, normal tissue may result in burns. [19]
The silver nitrate used for preventing gonorrhea and for cauterizing wounds is in a dilute solution. In concentrated forms, it is very toxic and dangerous. In itself, silver nitrate is quite toxic, which is why it is effective at preventing gonorrhea in the first place (it kills off the germs that cause the infection).
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