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Chloroquine retinopathy is a form of toxic retinopathy (damage of the retina) caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs. [3]
MDCalc is a free online medical reference for healthcare professionals that provides point-of-care clinical decision-support tools, including medical calculators, scoring systems, and algorithms. [1]
The calculator uses the proprietary HP Nut processor produced in a bulk CMOS process and featured continuous memory, whereby the contents of memory are preserved while the calculator is turned off. [13] Though commonplace now, this was still notable in the early 1980s, and is the origin of the "C" in the model name.
Toxic retinopathies, including those caused by Plaquenil and Vigabatrin. The ERG is also used to monitor retinal toxicity in many drug trials. Autoimmune retinopathies such as cancer associated retinopathy (CAR), melanoma associated retinopathy (MAR), and acute zonal occult outer retinopathy (AZOOR) Retinal detachment
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Hydroxychloroquine, sold under the brand name Plaquenil among others, is a medication used to prevent and treat malaria in areas where malaria remains sensitive to chloroquine. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth, often in the form of hydroxychloroquine sulfate. [3]
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The availability of 4,7-dichloroquinoline allowed alternative structural analogs of the 4-aminoquinoline type to be investigated, leading to the discovery of hydroxychloroquine in 1949. [ 5 ] [ 6 ] By that time, chloroquine manufacturing processes had been established to allow its widespread use.
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