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The choice of agent depends largely on specific pharmacological effects of individual agents with respect to the condition. One of the most important factors affecting inotropic state is the level of calcium in the cytoplasm of the muscle cell. Positive inotropes usually increase this level, while negative inotropes decrease it.
Negative inotropes improve left ventricular (LV) obstruction by decreasing LV ejection acceleration and hydrodynamic forces on the mitral valve. Disopyramide's particular efficacy is due to its potent negative inotropic effects; in head-to-head comparison, it is more effective for gradient reduction than either beta-blocker or verapamil. [16]
Fold mountains form in areas of thrust tectonics, such as where two tectonic plates move towards each other at convergent plate boundary.When plates and the continents riding on them collide or undergo subduction (that is – ride one over another), the accumulated layers of rock may crumple and fold like a tablecloth that is pushed across a table, particularly if there is a mechanically weak ...
Reducing the force of contraction of the myocardium is known as the negative inotropic effect of calcium channel blockers. Slowing down the conduction of electrical activity within the heart, by blocking the calcium channel during the plateau phase of the action potential of the heart (see: cardiac action potential ), results in a negative ...
Pages in category "Inotropic agents" The following 19 pages are in this category, out of 19 total. This list may not reflect recent changes. ...
Cardiotonic agents, also known as cardiac inotropes or stimulants, have a positive impact on the myocardium (muscular layer of the heart) by enhancing its contractility. . Unlike general inotropes, these agents exhibit a higher level of specificity as they selectively target the myocar
"Society of the Snow" is earning raves for its a ccurate depiction of the terrifying 1972 plane crash in the Andes mountains that involved a Uruguayan rugby team.. The new Netflix drama, directed ...
The effect can be either positive or negative, specifically a depolarization or a hyperpolarization respectively. This term is commonly confused with an inotropic effect, which refers to a change in the force of contraction (e.g. in heart muscle) produced by transmitter substances or hormones.