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The maximum lifespans of humans, naked mole-rats, and mice are respectively c. 120, 30 and 3 years. The longer-lived species, humans and naked mole-rats, expressed DNA repair genes, including core genes in several DNA repair pathways, at a higher level than did mice.
The naked mole rat has a disproportionately long life of 30 years through efficient cellular repair mechanisms. There are numerous studies that support cellular damage, often due to a lack of somatic maintenance mechanisms, as a primary determinant for aging, and these studies have given rise to the free radical theory of aging and the DNA ...
The DNA repair transcriptomes of the liver of humans, naked mole-rats and mice were compared. [114] The maximum lifespans of humans, naked mole-rat, and mouse are respectively ~120, 30 and 3 years. The longer-lived species, humans and naked mole rats expressed DNA repair genes, including core genes in several DNA repair pathways, at a higher ...
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The naked mole-rat has a particularly long life-span for a small rodent, about 30 years, and the basis for this longevity has been investigated. [46] Naked mole-rats express DNA repair genes, including core genes in several DNA repair pathways, at a higher level than shorter-lived mice, and thus it was suggested that DNA repair acts as a ...
The blesmols, also known as mole-rats, or African mole-rats, are burrowing rodents of the family Bathyergidae. They represent a distinct evolution of a subterranean life among rodents much like the pocket gophers of North America, the tuco-tucos in South America, and the Spalacidae from Eurasia.
Rochelle Buffenstein is an American comparative biologist currently working as Research Professor at the University of Illinois Chicago.Previously, she was a senior principal investigator at Calico Life Sciences, an Alphabet, Inc. funded research and development company investigating the biology that controls aging and lifespan where she used the extraordinarily long-lived cancer resistant ...
Storey's African mole-rat, Tachyoryctes storeyi Note that the Rhizomyinae do not include two other groups which also have the common name mole rats and are also found in Africa. The closely related subfamily Spalacinae consists of mole-like rodents found in Africa and the Middle East; these are also myomorphic rodents.