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Primary signet ring cell carcinoma of the colon and rectum (PSRCCR) is rare, with a reported incidence of less than 1 percent. It has a poor prognosis because symptoms often develop late and it is usually diagnosed at an advanced stage. Five-year survival rates in previous studies ranged from nine to 30 percent.
Over 40 percent of all mucinous carcinomas are colorectal. [1] When found within the skin, mucinous carcinoma is commonly a round, elevated, reddish, and sometimes ulcerated mass, usually located on the head and neck. [2]: 669
Tumor budding is a well-established independent marker of a potentially poor outcome in colorectal carcinoma that may allow for dividing people into risk categories more meaningful than those defined by TNM staging, and also potentially guide treatment decisions, especially in T1 and T3 N0 (Stage II, Dukes’ B) colorectal carcinoma.
Vacuoles are more prominent in mucinous tumors but can be seen in serous tumors as well. Adenocarcinoma [ 1 ] ( / ˌ æ d ɪ n oʊ k ɑːr s ɪ ˈ n oʊ m ə / ; plural adenocarcinomas or adenocarcinomata / ˌ æ d ɪ n oʊ k ɑːr s ɪ ˈ n oʊ m ə t ə / ; AC ) is a type of cancerous tumor that can occur in several parts of the body.
Pseudomyxoma peritonei (PMP) is a clinical condition caused by cancerous cells (mucinous adenocarcinoma) that produce abundant mucin or gelatinous ascites. [1] The tumors cause fibrosis of tissues and impede digestion or organ function, and if left untreated, the tumors and mucin they produce will fill the abdominal cavity.
Signet ring cell, as seen in a case of colon adenocarcinoma with mucinous features, showing a tumor cell with a vacuole of mucin. H&E stain. Signet ring for comparison. In histology, a signet ring cell is a cell with a large vacuole. The malignant type is seen predominantly in carcinomas.
The colorectal adenoma is a benign glandular tumor of the colon and the rectum. It is a precursor lesion of the colorectal adenocarcinoma ( colon cancer ). [ 1 ] [ 2 ] [ 3 ] They often manifest as colorectal polyps .
Urachal cancer usually is an adenocarcinoma (about 90%) mostly with mucinous/colloidal histology. Other rare types include urothelial carcinoma, squamous cell carcinoma, neuroendocrine carcinoma and sarcoma. [2] [4] [7] [8]
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