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Myelin is formed by oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system.Therefore, the first stage of myelinogenesis is often defined as the differentiation of oligodendrocyte progenitor cells (OPCs) or Schwann cell progenitors into their mature counterparts, [4] followed by myelin formation around axons.
This organization demands a tight developmental control and the formation of a variety of specialized zones of contact between different areas of the myelinating cell membrane. Each node of Ranvier is flanked by paranodal regions where helicoidally wrapped glial loops are attached to the axonal membrane by a septate-like junction.
This narrow zone is identified visually where there is a transition regarding myelin production. It is named after Emil Redlich and Heinrich Obersteiner. [1] As the Redlich–Obersteiner's zone separates the CNS and PNS, there is a transition from Schwann cell myelin to oligodendrocyte myelin. In cranial nerves this is often the place of neuro ...
Myelination gives metabolic support to, and insulates the axons of most vertebrates. [1] A single oligodendrocyte can extend its processes to cover up to 40 axons, that can include multiple adjacent axons. [2] The myelin sheath is not continuous but is segmented along the axon's length at gaps known as the nodes of Ranvier.
Myelination refers to the insulation of an axon with concentric surrounding layers of lipid membrane produced by Schwann cells. These layers are generally uniform and continuous, but due to imperfect nature of the process by which Schwann cells wrap the nerve axon, this wrapping process can sometimes leave behind small pockets of residual ...
Interventional magnetic resonance imaging, also interventional MRI or IMRI, is the use of magnetic resonance imaging (MRI) to do interventional radiology procedures.. Because of the lack of harmful effects on the patient and the operator, MR is well suited for "interventional radiology", where the images produced by an MRI scanner are used to guide a minimally-invasive procedure ...
The process creates a thinner myelin sheath than normal, but it helps to protect the axon from further damage, from overall degeneration, and proves to increase conductance once again. The processes underlying remyelination are under investigation in the hope of finding treatments for demyelinating diseases , such as multiple sclerosis .
He derived a map of the cerebral cortex divided not by histology (as Korbinian Brodmann did) but by order of myelination. Flechsig divided the cortical regions into: an early myelinating primitive zone, which includes the motor cortex and the visual, auditory, and somatosensory cortex; a field bordering the primitive zone that myelinates next;