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Nevertheless, even the best 3D culture models fail to mimic an organ's cellular properties in many aspects, [6] including tissue-to-tissue interfaces (e.g., epithelium and vascular endothelium), spatiotemporal gradients of chemicals, and the mechanically active microenvironments (e.g. arteries' vasoconstriction and vasodilator responses to ...
Schematic drawing of a lung-on-a-chip. The membrane in the middle can be stretched by vacuum in the two side chambers. Lung-on-a-chip (LoC), also known as Lung Chips, are micro- and millifluidic organ-on-a-chip devices designed to replicate the structure and function of the human lung, mimicking the breathing motions and fluid dynamics that occur during inhalation and exhalation. [1]
Organ chips are devices containing hollow microvessels filled with cells simulating tissue and/or organs as a microfluidic system that can provide key chemical and electrical signal information. [48] This is distinct from an alternative use of the term microchip , which refers to small, electronic chips that are commonly used as an identifier ...
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Emulate's Organs-on-Chips technology has been used to recreate the function of a variety of different organs, including the liver, intestine, brain, kidney, and lung. [5] The company's Organ-Chips are about the size of a AA battery and feature two fluidic channels that create the flow of blood and other fluids.
Organoids are derived from three kinds of human or animal stem cells—embryonic pluripotent stem cells (ESCs), adult somatic stem cells (ASCs), and induced pluripotent stem cells (iPSCs). These organoids are grown in vitro and mimic the structure and function of different organs such as the brain, liver, lung, kidney, and intestine. Organoids ...
Microplastics that have been found in human organs have “alarming links” to adverse health impacts, including lesions, cervical cancer, and other diseases, researchers suggest. Now, an ...
Overall, microfluidic devices increase the control over the organ-specific microenvironment, which allows for more precise models. [ 7 ] Different technologies have been used to introduce microfluidic flows in intestine-on-a-chip devices, including peristaltic pumps , [ 10 ] syringe pumps , [ 11 ] pressure generators [ 12 ] and pumpless systems ...