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2. Management of depression - Wikipedia

   en.wikipedia.org/wiki/Management_of_depression

   The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...

3. Shock therapy (psychiatry) - Wikipedia

   en.wikipedia.org/wiki/Shock_therapy_(psychiatry)

   Deep sleep therapy, introduced in the late 20th century, involved placing patients into a drug-induced coma for extended periods, purportedly to treat various mental illnesses.< [5] This approach to mental health treatment was part of a broader search for effective therapies during a time when the psychiatric field was struggling with managing ...

4. Mode deactivation therapy - Wikipedia

   en.wikipedia.org/wiki/Mode_Deactivation_Therapy

   Mode deactivation therapy (MDT) is a psychotherapeutic approach that addresses dysfunctional emotions, maladaptive behaviors and cognitive processes and contents through a number of goal-oriented, explicit systematic procedures.

5. Cognitive behavioral analysis system of psychotherapy

   en.wikipedia.org/wiki/Cognitive_behavioral...

   Absence of felt interpersonal safety in patients. Chronic mood (e.g., chronic depression) denotes an absence of felt safety as regards (a) the precipitating (original) trauma event(s) or on a less sudden and violent level, (b) maltreating-hurtful significant others who have inflicted psychological insults on the individual through interpersonal rejection, harsh punishment, censure, or ...

6. Dextromethorphan/bupropion - Wikipedia

   en.wikipedia.org/wiki/Dextromethorphan/bupropion

   [1] [3] [4] [5] The scores shown are the mean total depression scores on the MADRS over 6 weeks. Only 124/156 patients completed 6 weeks of Auvelity while 150/162 patients completed 6 weeks of placebo, consistent with a high rate of adverse reactions. [4] [5] [2] Dextromethorphan/bupropion is approved for the treatment of major depressive ...

7. Treatment-resistant depression - Wikipedia

   en.wikipedia.org/wiki/Treatment-resistant_depression

   In 2018, the United States Food and Drug Administration (FDA) granted breakthrough therapy designation for psilocybin-assisted therapy for treatment-resistant depression. [ 28 ] [ 29 ] A systematic review published in 2021 found that the use of psilocybin as a pharmaceutical substance was associated with reduced intensity of depression symptoms.