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Crackles are more common during the inspiratory than the expiratory phase of breathing, but they may be heard during the expiratory phase. Crackles are often described as fine, medium, and coarse. They can also be characterized as to their timing: fine crackles are usually late-inspiratory, whereas coarse crackles are early inspiratory.
Respiratory sounds, also known as lung sounds or breath sounds, are the specific sounds generated by the movement of air through the respiratory system. [1] These may be easily audible or identified through auscultation of the respiratory system through the lung fields with a stethoscope as well as from the spectral characteristics of lung sounds. [2]
Crackles or rales. Intermittent, non-musical and brief sounds heard during inspiration only. They may be described as fine (soft, high-pitched) or coarse (louder, low-pitched). These are the result of alveoli opening due to increased air pressure during inspiration.
Other signs include end-inspiratory crackles (crackling sounds heard at the end of a deep breath) on auscultation and the presence of a third heart sound. [3] Shortness of breath can manifest as orthopnea (inability to breathe sufficiently when lying down flat) and/or paroxysmal nocturnal dyspnea (episodes of severe sudden breathlessness at ...
It can be inspiratory, expiratory or biphasic, although it is usually heard during inspiration. Inspiratory stridor often occurs in children with croup. It may be indicative of serious airway obstruction from severe conditions such as epiglottitis, a foreign body lodged in the airway, or a laryngeal tumor. Stridor should always command ...
IL-13 is a cytokine involved in regulating immune responses. [21] It has been shown to promote fibrosis in the lungs by stimulating the production of ECM proteins and the recruitment of fibroblasts to sites of tissue injury. PDGF is a cytokine that plays a key role in the regulation of cell proliferation and migration. [22]
Sniff nasal inspiratory pressure (SNIP) refers to short, sharp voluntary inspiratory maneuver (inhalation) through one or both un-occluded (not closed or obstructed) nostrils. The tests are performed at FRC (functional residual capacity), at the end of tidal expiration. The measurement recorded is the peak pressure.
Dry, inspiratory bilateral basal crackles on auscultation (a crackling or popping sound in the lungs during inhalation). [3] [12] [13] Clubbing of the digits, a disfigurement of the finger tips or toes (see image) Abnormal pulmonary function test results, with evidence of restriction and impaired gas exchange.