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Whereas the IC 50 value for a compound may vary between experiments depending on experimental conditions, (e.g. substrate and enzyme concentrations) the K i is an absolute value. K i is the inhibition constant for a drug; the concentration of competing ligand in a competition assay which would occupy 50% of the receptors if no ligand were present.
Ligand efficiency is a measurement of the binding energy per atom of a ligand to its binding partner, such as a receptor or enzyme. [1]Ligand efficiency is used in drug discovery research programs to assist in narrowing focus to lead compounds with optimal combinations of physicochemical properties and pharmacological properties.
Toxic units (TU) are used in the field of toxicology to quantify the interactions of toxicants in binary mixtures of chemicals. [1] A toxic unit for a given compound is based on the concentration at which there is a 50% effect (ex. EC50) for a certain biological endpoint.
The term "potency" refers to the EC 50 value. The lower the EC 50, the less the concentration of a drug is required to produce 50% of maximum effect and the higher the potency. The EC 10 and EC 90 concentrations to induce 10% and 90% maximal responses are defined similarly.
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The hastily assembled show that morning included analysis from Today news anchor Jim Fleming, who once worked in NBC's Moscow bureau, and veteran NBC foreign correspondent Hans von Kaltenborn. Alexander Kerensky , a former leader of the Russian Provisional Government , was awakened and brought to the RCA Exhibition Hall to add his commentary on ...
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Today (also called The Today Show) is an American morning television show that airs weekdays from 7:00 a.m. to 11:00 a.m. on NBC.The program debuted on January 14, 1952. It was the first of its genre on American television and in the world, and after 73 years of broadcasting it is fifth on the list of longest-running American television serie