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Serotonin syndrome (SS) is a group of symptoms that may occur with the use of certain serotonergic medications or drugs. [1] The symptoms can range from mild to severe, and are potentially fatal. [4] [5] [2] Symptoms in mild cases include high blood pressure and a fast heart rate; usually without a fever. [2]
More severe symptoms include fever, seizures, irregular heartbeat, delirium, and coma. [76] [77] [11] If signs or symptoms arise, discontinue treatment with serotonergic agents immediately. [76] It is recommended to washout 4 to 5 half-lives of the serotonergic agent before using an MAO inhibitor. [78]
The observation of this efficacy led to the monoamine hypothesis of depression, which postulates that the deficit of certain neurotransmitters is responsible for depression, and even that certain neurotransmitters are linked to specific symptoms. Normal serotonin levels have been linked to mood and behaviour regulation, sleep, and digestion ...
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You may have heard the phrase used to describe people who function at a high level despite having anxiety symptoms. People with high-functioning anxiety are typically high-achievers ...
The reason why serotonin levels are only high in dominant males, but not dominant females has not yet been established. [ 68 ] In humans, levels of 5-HT 1A receptor inhibition in the brain show negative correlation with aggression, [ 69 ] and a mutation in the gene that codes for the 5-HT 2A receptor may double the risk of suicide for those ...
Being female — binge eating disorder is more common in women than men Having type 1 or type 2 diabetes — perhaps because of the increased focus on food and weight Experiencing childhood trauma ...
The exact pathogenesis of the disorder is still unclear and is an active research topic. Treatment of PMDD relies largely on antidepressants that modulate serotonin levels in the brain via serotonin reuptake inhibitors as well as ovulation suppression using contraception. [22] [23]