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Consistency and viscosity affect the adhesion and retention property of the gel, and are important in ensuring the gel is retained at the site of application and effective delivery of the drug. [ 3 ] The ingredients in topical gel formulation can be broadly categorized into four types: gelator, solvent, drug, and excipients.
The exact mechanism of action of silicone gel sheeting has not been fully studied. Currently, many proposed mechanisms explain the efficacy of such treatment, including the occlusion and hydration effect, increased body surface temperature, polarized electric charge, immunological effects, etc. [9] The occlusion and hydration effect is the most studied mechanism of action.
Gelatin, here in sheets for cooking, is a hydrogel. Peptide hydrogel formation shown by the inverted vial method. A hydrogel is a biphasic material, a mixture of porous and permeable solids and at least 10% of water or other interstitial fluid.
A container with cream. Topical cream formulation is an emulsion semisolid dosage form that is used for skin external application. Most of the topical cream formulations contain more than 20 per cent of water and volatiles and/or less than 50 per cent of hydrocarbons, waxes, or polyethylene glycols as the vehicle for external skin application. [1]
The gel may be designed to drain, or to remain within the structure of the adhesive matrix. [ 4 ] The moist conditions produced under the dressing are intended to promote fibrinolysis , angiogenesis and wound healing, without causing softening and breaking down of tissue.
Aluminium oxynitride (marketed under the name ALON by Surmet Corporation [3]) is a transparent ceramic composed of aluminium, oxygen and nitrogen.Aluminium oxynitride is optically transparent (≥80% for 2 mm thickness) in the near-ultraviolet, visible, and mid-wave-infrared regions of the electromagnetic spectrum.
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