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Microangiopathy (also known as microvascular disease, small vessel disease (SVD) or microvascular dysfunction) is a disease of the microvessels, small blood vessels in the microcirculation. [1] It can be contrasted to macroangiopathies such as atherosclerosis , where large and medium-sized arteries (e.g., aorta , carotid and coronary arteries ...
Mental stress-induced myocardial ischemia involves abnormal microvascular vasoreactivity and inflammation, with increased brain activity in regions that modulate autonomic nervous system reactivity to emotional stress, fear. [2] [7] Emotional responses and certain psychological traits may influence the occurrence of MSIMI. [6]
Abnormal cardiac stress test: ST segment changes in EKG are typically similar to those of coronary artery disease, and the opposite of those of Prinzmetal's angina. Myocardial perfusion imaging can be abnormal in 30% of patients. Coronary angiogram: Normal; Other causes of chest pain must be ruled out, including: Variant angina / Coronary ...
The primary cause of microvascular angina is unknown, but factors apparently involved are endothelial dysfunction and reduced flow (perhaps due to spasm) in the tiny "resistance" blood vessels of the heart. [18] Since microvascular angina is not characterized by major arterial blockages, it is harder to recognize and diagnose. [19] [20] [21]
Ischemia causes not only insufficiency of oxygen, but also reduced availability of nutrients and inadequate removal of metabolic wastes. [7] Ischemia can be partial (poor perfusion) or total blockage. The inadequate delivery of oxygenated blood to the organs must be resolved either by treating the cause of the inadequate delivery or reducing ...
Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the body, blocking small blood vessels. [1] Symptoms may include chest pain, shortness of breath, leg pain, problems speaking, or problems moving parts of the body. [1]
Globally, it causes about 10 million deaths per year. Atherosclerosis is characterized by the build-up of plaque inside your blood vessels. It can lead to stenosis, which is a narrowing of your ...
Researchers have identified common pathways and links between TTP and HUS, [2] [6] while other sources express skepticism about their common pathophysiology. [7] The repression of the vascular endothelial growth factor (VEGF) can also cause glomerular TMA (damage to the glomerular microvasculature). It is likely that the absence of VEGF results ...