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Anastrozole, sold under the brand name Arimidex among others, is an antiestrogenic medication used in addition to other treatments for breast cancer. [6] [7] Specifically it is used for hormone receptor-positive breast cancer. [7] It has also been used to prevent breast cancer in those at high risk. [7] It is taken by mouth. [7]
Tamoxifen (a SERM) traditionally was the drug treatment of choice, but the ATAC trial (Arimidex, Tamoxifen, Alone or in Combination) showed that in women with localized estrogen receptor-positive breast cancer, women receiving the AI anastrozole had better results than the tamoxifen group. [4]
Steroidal aromatase inhibitors are a class of drugs that are mostly used for treating breast cancer in postmenopausal women. High levels of estrogen in breast tissue increases the risk of developing breast cancer and the enzyme aromatase is considered to be a good therapeutic target when treating breast cancer due to it being involved in the final step of estrogen biosynthetic pathway and also ...
AstraZeneca Launches New Digital Resources for ARIMIDEX ® (anastrozole) Tablets to Help Educate Patients About ARIMIDEX Direct Resources Provide Program Enrollment Information and Encourage ...
These treatments can include selective estrogen receptor modulators like clomiphene , a derivative of clomiphene called enclomiphene, or aromatase inhibitors like anastrozole (Arimidex®). These ...
Third-generation, anastrozole and letrozole are very selective, they only inhibit the aromatase enzyme and do not have an effect on other steroidogenic pathways. [21] Mechanism of NSAIs is a reversible binding process where NSAIs binds to the aromatase enzyme through non-covalent interactions. [22] NSAIs do not destroy the enzyme like SAIs do.
Nolvadex 20 mg tablets Arimidex (anastrozole) 1 mg tablets. One effective strategy for starving tumor cells of growth- and survival-promoting hormones is to use drugs which inhibit the production of those hormones in their organ of origin.
[132] [133] In accordance, antiestrogens like the selective estrogen receptor modulator (SERM) tamoxifen, the ER antagonist fulvestrant, and the aromatase inhibitors (AIs) anastrozole and exemestane are all effective in the treatment of ER-positive breast cancer. [134] [135] [136] Antiestrogens are also effective in the prevention of breast cancer.
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109 S High St #100, Columbus, OH · Directions · (614) 224-4261