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While needlestick injuries have the potential to transmit bacteria, protozoa, viruses and prions, [6] the risk of contracting hepatitis B, hepatitis C, and HIV is the highest. [7] The World Health Organization estimated that in 2000, 66,000 hepatitis B, 16,000 hepatitis C, and 1,000 HIV infections were caused by needlestick injuries.
In the case of HIV exposure, post-exposure prophylaxis (PEP) is a course of antiretroviral drugs which reduces the risk of seroconversion after events with high risk of exposure to HIV (e.g., unprotected anal or vaginal sex, needlestick injuries, or sharing needles). [22]
A course of antiretrovirals administered within 48 to 72 hours after exposure to HIV-positive blood or genital secretions is referred to as post-exposure prophylaxis. [52] The use of the single agent zidovudine reduces the risk of subsequent HIV infection fivefold following a needle stick injury. [52]
The risk of acquiring HIV from a needle stick from an HIV-infected person is estimated as 0.3% (about 1 in 333) per act and the risk following mucous membrane exposure to infected blood as 0.09% (about 1 in 1000) per act. [54] This risk may, however, be up to 5% if the introduced blood was from a person with a high viral load and the cut was ...
In 2022, Oklahoma ranked among the top seven states in the United States with the highest rural burden of HIV. Each case costs the state nearly $510,000 a lifetime, according to Brittany Hayes ...
Efavirenz (EFV), sold under the brand names Sustiva among others, is an antiretroviral medication used to treat and prevent HIV/AIDS. [1] It is generally recommended for use with other antiretrovirals. [1] It may be used for prevention after a needlestick injury or other potential exposure. [1]
The US Institute of Medicine evaluated the conflicting evidence of both Drs Wodak [78] and Käll [79] in their Geneva session [80] and concluded that although multicomponent HIV prevention programmes that include needle and syringe exchange reduced intermediate HIV risk behavior, evidence regarding the effect of needle and syringe exchange ...
In the United Kingdom the BHIVA/BASHH guidelines on the use of HIV pre-exposure prophylaxis (PrEP) 2018 [7] recommend: On-demand or daily oral Tenofovir – emtricitabine (TD-FTC) for HIV-negative MSM who are at elevated risk of HIV acquisition through unprotected anal sex in the previous six months and ongoing unprotected anal sex.